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  1. JACS
    CATALYTIC CO2 REDUCTION BY PALLADIUM
    DECORATED SILICON HYDRIDE NANOSHEETS
    The Ozin Group shows how decorating silicon nonosheets with palladium
    nanoparticles renders the process catalytic, a breakthrough with far
    reaching technological implications.
    Ozin group, Nature Catalysis, 2019
  2. JACS
    UNUSUAL REARRANGEMENT OF AN
    N-DONOR-FUNCTIONALIZED N-HETEROCYCLIC
    CARBENE LIGAND ON GROUP 8 METALS
    The Song group discovered an unusual rearrangement reaction,where
    the N,C-chelate ligand of a piano-stool Group 8complex isomerizes into
    an N,N-chelate ligand. Mechanistic study suggests the involvement of a
    high-energy metal-alkylidene intermediate.
    Song group, Journal of the American Chemical Society, 2018
  3. Cell
    DYSREGULATION OF MITOCHONDRIAL CLPP
    PROTEASE AS A POTENTIAL STRATEGY TO
    DEVELOP NOVEL ANTICANCERS
    Human mitochondrial ClpP was found to be activated by specific
    acyldepsipeptide compounds causing apoptotic cell death.
    Houry and Batey groups, Cell Chemical Biology, 2018
  4. Nature
    AMINE HEMILABILITY ENABLES BORON TO
    MECHANISTICALLY RESEMBLE EITHER
    HYDRIDE OR PROTON
    Mechanistic studies of the hemilability of MIDA
    (N-methyliminodiacetic acid) boronates reveal the chameleonic
    behaviour of the BMIDA group.
    Yudin group, Nature Chemistry, 2018
  5. Nature
    TIPPING CELL SIGNALING PATHWAYS BY SALTS
    Mechanistic insights into allosteric regulation ofthe A2A adenosine
    G protein-coupled receptor byphysiological cations.
    Prosser group, Nature Communications, 2018
  6. Journal of the American Chemical Society
    COMPETITIVE SELF-ASSEMBLY KINETICS AS A
    ROUTE TO CONTROLLING MORPHOLOGY OF
    CORE-CRYSTALLINE CYLINDRICAL MICELLESS
    One can manipulate the seeded-growth kinetics of block
    copolymer unimers to control the growth sequence of
    unimers and thus the comicelle morphology.
    Winnik group, Journal of the American Chemical Society, 2018
  7. Oncogene
    INHIBITING MYC BINDING TO THE E-BOX DNA
    MOTIF BY ME47 DECREASES
    TUMOUR XENOGRAFT GROWTH
    The Shin lab's designed protein ME47 decreased tumor growth in
    a triple negative breast cancer mouse model, a type of cancer with
    no effective treatments.
    Shin, Chan & Penn groups, Oncogene, 2017

Awards:

Chris Caputo awarded 2018 Polanyi Prize

Chris Caputo awarded 2018 Polanyi Prize

Congratulations to Chris Caputo (PhD '15, Stephan Group) for being one of five Ontario researchers honoured in the online gambling2018 Polanyi Prizes.

Chris is being recognized for research that focuses on how to use “main group?chemicals ?common, non-metal elements such as boron and phosphorous ? to take their place as catalysts. This means manipulating them to create molecules that can mimic the high reactivity of precious metals.


News and Announcements:

Startup from the lab of Professor Molly Shoichet raises $3.25 million to eliminate prescription opioids after surgery

Startup from the lab of Professor Molly Shoichet raises $3.25 million to eliminate prescription opioids after surgery

A U of T startup has raised $3.25 million to online gamblingdevelop a gel-based drug delivery system that could eliminate the need to give patients powerful painkillers following surgery ?a key source of the current opioid crisis.

The startup, AmacaThera, is built on a gel technology developed in the lab of Professor Molly Shoichet that dramatically extends the duration of anesthetics injected at the site of a surgical incision.


Professor Geoff Ozin: 'The story of CO2 needs altering'

Professor Geoff Ozin: 'The story of CO2 needs altering'

Professor Geoff Ozin writes in online gamblingAdvanced Science News about the "rapid dissemination of misleading, confusing, frightening and false information" in science, particularly when it relates to carbon dioxide.

"By regarding CO2 as a friend rather than a foe, to see it as a recyclable feedstock for making value-added products, rather than a polluting waste, people can begin to appreciate how it could actually prevent the next mass extinction of life on earth, rather than being the cause."


Professor Andrei Yudin appointed as Associate Editor at Chemical Science

Professor Andrei Yudin appointed as Associate Editor at Chemical Science

Professor Andrei Yudin online gamblinghas been named Associate Editor at Chemical Science.

Professor Yudin will handle submissions in the areas of organic synthesis, transition metal catalysis, peptide preparation and macrocyclisation.






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Optimizing NMR Methods for Structure Elucidation: Characterizing Natural Products and Other Organic Compounds
This book is aimed at informing organic chemists and natural products chemists on the use of NMR for structure elucidation to enable them to ensure they yield the most reliable possible data in the ...

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